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KMID : 0854720080280010035
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Korean Journal of Asthma, Allergy and Clinical Immunology
2008 Volume.28 No. 1 p.35 ~ p.39
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Clinical Features of Adeverse Drug Reactions in a Tertiary Care Hospital in Korea
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Kim Myung-Hyun
Son Myoung-Kyun
Park Jung-Won
Hong Chein-Soo
Jung Han-Young
Lee Yong-Won
Kim Sung-Eun
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Abstract
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Background: Clinical features of adverse drug reactions (ADR) are different and the incidence is increasing. However, there have been only a few data on the clinical features of ADR in Korea.
Method: We prospectively collected ADR cases at Severance Hospital between October 2003 and April 2006, analyzed the clinical features.
Result: Three hundred and fifty-seven ADR cases were reported. The most common causative drugs were radiocontrast media and nonsteroidal anti-inflammatory drugs (NSAIDs), followed by anticonvulsants, such as lamotrigine, carbamazepine, theophyllines and cephalosporins. Most of the causative radiocontrast media were nonionic, low molecular and iodinated. The leading clinical features were skin eruptions and urticaria. Nine cases of serious ADR were induced by general medication, including 1 case of mortality due to allopurinol-induced toxic epidermal necrolysis. ADR cases induced by contrast media were 245.
Conclusion: The most common causative drugs which induced adverse drug reactions were NSAIDs and radiocontrast media. The leading clinical features were skin eruptions and urticaria. Among radiocontrast media, nonionic low molecular iodinated contrast media mainly induced adverse drug reactions. Further epidemiologic studies will validate our study and help reveal the incidence of ADR in Korea.
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KEYWORD
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Adeverse Drug Reaction, NSAID, Radiocontrast media
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